Objective. To analyze the topographic approach and features of facial soft tissue preparation when entering the deep cellular spaces.

Material and methods. We prepared 28 unfixed fresh frozen cadaveric materials on both sides of the face with preliminary vascular contrast enhancement by Landolfi with silicone compound. All facial cellular spaces were prepared in layer by layer fashion on both sides. We established their topographic relationships and dangerous nuances of surgical intervention.

Results. We identified the main topographic structures of deep facial plane and their relationships, safe method for deep mobilization of facial tissues. The last one implies safe passage in zygomatic and masticatory space, their connection, mobilization and fixation.

Conclusion. This topographic study substantiated safe mobilization of deep tissues and its introduction into widespread clinical practice.

Keywords. topographic approach, deep cellular spaces, facial tissues